Skills

Statistics

90%

Machine larning

90%

Genomics

90%

R

90%

Python

90%

Bash

90%

Experience

 
 
 
 
 
April 2019 – March 2020
Atlanta, GA

Mathematical Statistician

Centers for Disease Control and Prevention

Responsibilities include:

  • Develop advanced statistical models to integrate genomic and epidemiological data to detect anomaly disease clusters to triage foodborne outbreak detection
  • Develop R Shiny apps to facilate big data visualization and results presentation to promote communications with epidemiologists
 
 
 
 
 
April 2015 – March 2019
Pittsburgh, PA

Postdoctoral Research Associate

Ma Laboratory, Computaional Biology Department, Carnegie Mellon University

Responsibilities include:

  • Develop clustering method to identify heterogeneous clusters from heterogeneous networks
  • Explore the connection between 3D chromatin interactome and gene regulatory network
  • Jointly clustering single-cell transcriptome and chromatin accessibility data by utilizing gene regulatory network
 
 
 
 
 
May 2011 – February 2015
Singapore

Part-time Statistician

Singapore Eye Research Institute

Provide statistical analysis and consultation

Manuscripts

Tian D, Zhu X, Ma J. Diffdomain enables detection of reshaped chromatin domains using random matrix theory.

Tian D, Ma J. Exploiting the interplay between chromatin interactome and transcriptional regulatory network.

Publications

* represents co-first authors.

Tian D*, Zhang R*, Zhang Y, Zhu X, Ma J. MOCHI enables discovery of heterogeneous interactome modules in 3D nucleome. Genome Research. 30, 2 (2020). Link

Tian D, Gu Q, Ma J. Identifying gene regulatory network rewiring using latent differential graphical models. Nucleic Acids Research. 4, 44 (2016). Link

Zhang, S*, Tian, D*, Tran, NH, Choi, KP, & Zhang, L. Profiling the transcription factor regulatory networks of human cell types. Nucleic Acids Research, 42, 20 (2014). Link

Tian D, Choi KP. Sharp bounds and normalization of wiener-type indices. PLOS ONE. 8, 8 (2013). Link

Collaboration papers

Chen, L., Cheng, C.Y., Choi, H., Ikram, M.K., Sabanayagam, C., Tan, G.S., Tian, D., Zhang, L., Venkatesan, G., Tai, E.S. and Wang, J.J.. Plasma metabonomic profiling of diabetic retinopathy. Diabetes. 2016 p.db150661. Link

Koh V, Cheung CY, Li X, Tian D, Wang JJ, Mitchell P, Cheng CY, Wong TY. Retinal vein occlusion in a multi-ethnic Asian population: the Singapore Epidemiology of Eye Disease Study. Ophthalmic epidemiology. 2016 Jan 2;23(1):6-13. Link

Yam GH, Yusoff NZ, Kadaba A, Tian D, Myint HH, Beuerman RW, Zhou L, Mehta JS. Ex vivo propagation of human corneal stromal “activated keratocytes” for tissue engineering. Cell transplantation. 2015 Sep 14;24(9):1845-61. Link

Chen L, Li J, Guo T, Ghosh S, Koh SK, Tian D, Zhang L, Jia D, Beuerman RW, Aebersold R, Chan EC. Global metabonomic and proteomic analysis of human conjunctival epithelial cells (IOBA-NHC) in response to hyperosmotic stress. Journal of proteome research. 2015 Aug 19;14(9):3982-95. Link

Tong L, Zhou XY, Jylha A, Aapola U, Liu DN, Koh SK, Tian D, Quah J, Uusitalo H, Beuerman RW, Zhou L. Quantitation of 47 human tear proteins using high resolution multiple reaction monitoring (HR-MRM) based-mass spectrometry. Journal of proteomics. 2015 Feb 6;115:36-48. Link

Barathi VA, Chaurasia SS, Poidinger M, Koh SK, Tian D, Ho C, Iuvone PM, Beuerman RW, Zhou L. Involvement of GABA transporters in atropine-treated myopic retina as revealed by iTRAQ quantitative proteomics. Journal of proteome research. 2014 Oct 1;13(11):4647-58. Link

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